In today’s competitive academic environment, students face numerous challenges such as examination anxiety, lack of motivation to attend classes, and difficulty in understanding subject matter, which may hinder their academic performance. Academic stress is a major source of stress among adolescents. Stress is defined as the body’s non-specific response to demands or disturbing events in the environment. While excessive stress hampers learning, an optimal level of stress can enhance learning ability. The present study aims to examine whether significant differences exist in academic stress among high school students with respect to region and type of school. A simple random sampling technique was adopted, and the sample comprised 500 high school students from Chennai district. Data were analysed using critical ratio and one-way analysis of variance. The findings reveal a significant difference in academic stress based on region, whereas no significant difference was found based on type of school.