This article examines innovative pedagogical strategies tailored to 21st-century higher education in India, with a focused lens on the transformative framework of NEP 2020. It outlines the policy’s pedagogical mandates emphasizing learner-centricity, interdisciplinarity, digital integration, and teacher empowerment. Key strategies—such as activity-based learning, MOOCs and SWAYAM, Virtual Labs, technology-mediated and flipped classroom models—are explored within Indian higher education and teacher education institutions. The paper discusses policy shifts affecting teacher preparation including the four-year integrated B.Ed, multidisciplinary Teacher Education Institutions (TEIs), and professional development via SWAYAM/DIKSHA. Case illustrations include Virtual Labs, IIT-Bombay’s Educational Technology programme, and university innovations like the University of Rajasthan’s SWAYAM integration. Constraints such as cultural resistance, infrastructure inequities, and faculty skills gaps are examined. The article concludes with recommendations: building digital infrastructure, faculty capacity building, inclusive pedagogical design, and interdisciplinary collaboration—all vital to realizing NEP 2020’s vision of educational innovation and equity.